A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

Precise regulation of centrosome number is critical for accurate chromosome segregation and the maintenance of genomic integrity. In nontransformed cells, centrosome loss triggers a p53-dependent surveillance pathway that protects against genome instability by blocking cell growth. However, the mech...

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Detaylı Bibliyografya
Yayımlandı:J Cell Biol
Asıl Yazarlar: Lambrus, Bramwell G., Daggubati, Vikas, Uetake, Yumi, Scott, Phillip M., Clutario, Kevin M., Sluder, Greenfield, Holland, Andrew J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2016
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949452/
https://ncbi.nlm.nih.gov/pubmed/27432896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201604054
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