A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

Precise regulation of centrosome number is critical for accurate chromosome segregation and the maintenance of genomic integrity. In nontransformed cells, centrosome loss triggers a p53-dependent surveillance pathway that protects against genome instability by blocking cell growth. However, the mech...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Lambrus, Bramwell G., Daggubati, Vikas, Uetake, Yumi, Scott, Phillip M., Clutario, Kevin M., Sluder, Greenfield, Holland, Andrew J.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949452/
https://ncbi.nlm.nih.gov/pubmed/27432896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201604054
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