Chargement en cours...
A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis
Precise regulation of centrosome number is critical for accurate chromosome segregation and the maintenance of genomic integrity. In nontransformed cells, centrosome loss triggers a p53-dependent surveillance pathway that protects against genome instability by blocking cell growth. However, the mech...
Enregistré dans:
| Publié dans: | J Cell Biol |
|---|---|
| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2016
|
| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4949452/ https://ncbi.nlm.nih.gov/pubmed/27432896 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201604054 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|