A USP28–53BP1–p53–p21 signaling axis arrests growth after centrosome loss or prolonged mitosis

Precise regulation of centrosome number is critical for accurate chromosome segregation and the maintenance of genomic integrity. In nontransformed cells, centrosome loss triggers a p53-dependent surveillance pathway that protects against genome instability by blocking cell growth. However, the mech...

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Dades bibliogràfiques
Publicat a:J Cell Biol
Autors principals: Lambrus, Bramwell G., Daggubati, Vikas, Uetake, Yumi, Scott, Phillip M., Clutario, Kevin M., Sluder, Greenfield, Holland, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949452/
https://ncbi.nlm.nih.gov/pubmed/27432896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201604054
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