53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

In normal human cells, centrosome loss induced by centrinone—a specific centrosome duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown mechanism. A genome-wide CRISPR/Cas9 screen for centrinone resistance identified genes encoding the p53-binding protein 53BP1, the deu...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Meitinger, Franz, Anzola, John V., Kaulich, Manuel, Richardson, Amelia, Stender, Joshua D., Benner, Christopher, Glass, Christopher K., Dowdy, Steven F., Desai, Arshad, Shiau, Andrew K., Oegema, Karen
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2016
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949453/
https://ncbi.nlm.nih.gov/pubmed/27432897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201604081
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