53BP1 and USP28 mediate p53 activation and G1 arrest after centrosome loss or extended mitotic duration

In normal human cells, centrosome loss induced by centrinone—a specific centrosome duplication inhibitor—leads to irreversible, p53-dependent G1 arrest by an unknown mechanism. A genome-wide CRISPR/Cas9 screen for centrinone resistance identified genes encoding the p53-binding protein 53BP1, the deu...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:J Cell Biol
Autors principals: Meitinger, Franz, Anzola, John V., Kaulich, Manuel, Richardson, Amelia, Stender, Joshua D., Benner, Christopher, Glass, Christopher K., Dowdy, Steven F., Desai, Arshad, Shiau, Andrew K., Oegema, Karen
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2016
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949453/
https://ncbi.nlm.nih.gov/pubmed/27432897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201604081
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars