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Centriole-independent mitotic spindle assembly relies on the PCNT–CDK5RAP2 pericentriolar matrix
Centrosomes, composed of centrioles that recruit a pericentriolar material (PCM) matrix assembled from PCNT and CDK5RAP2, catalyze mitotic spindle assembly. Here, we inhibit centriole formation and/or remove PCNT–CDK5RAP2 in RPE1 cells to address their relative contributions to spindle formation. Wh...
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7658699/ https://ncbi.nlm.nih.gov/pubmed/33170211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.202006010 |
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