Centrosome defects cause microcephaly by activating the 53BP1‐USP28‐TP53 mitotic surveillance pathway

Mutations in centrosome genes deplete neural progenitor cells (NPCs) during brain development, causing microcephaly. While NPC attrition is linked to TP53‐mediated cell death in several microcephaly models, how TP53 is activated remains unclear. In cultured cells, mitotic delays resulting from centr...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Phan, Thao P, Maryniak, Aubrey L, Boatwright, Christina A, Lee, Junsu, Atkins, Alisa, Tijhuis, Andrea, Spierings, Diana CJ, Bazzi, Hisham, Foijer, Floris, Jordan, Philip W, Stracker, Travis H, Holland, Andrew J
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7780150/
https://ncbi.nlm.nih.gov/pubmed/33226141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020106118
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