CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination

CEP63 is a centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response. Mutations in CEP63 cause Seckel syndrome, a human disease characterized by microcephaly and dwarfism. Here we demonstrate that Cep63 deficient mice recapitulate Seckel syndrome patholog...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Nat Commun
मुख्य लेखकों: Marjanović, Marko, Sánchez-Huertas, Carlos, Terré, Berta, Gómez, Rocío, Scheel, Jan Frederik, Pacheco, Sarai, Knobel, Philip A., Martínez-Marchal, Ana, Aivio, Suvi, Palenzuela, Lluís, Wolfrum, Uwe, McKinnon, Peter J., Suja, José A., Roig, Ignasi, Costanzo, Vincenzo, Lüders, Jens, Stracker, Travis H.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2015
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499871/
https://ncbi.nlm.nih.gov/pubmed/26158450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8676
टैग : टैग जोड़ें
कोई टैग नहीं, इस रिकॉर्ड को टैग करने वाले पहले व्यक्ति बनें!

समान संसाधन