CEP63 deficiency promotes p53-dependent microcephaly and reveals a role for the centrosome in meiotic recombination

CEP63 is a centrosomal protein that facilitates centriole duplication and is regulated by the DNA damage response. Mutations in CEP63 cause Seckel syndrome, a human disease characterized by microcephaly and dwarfism. Here we demonstrate that Cep63 deficient mice recapitulate Seckel syndrome patholog...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Marjanović, Marko, Sánchez-Huertas, Carlos, Terré, Berta, Gómez, Rocío, Scheel, Jan Frederik, Pacheco, Sarai, Knobel, Philip A., Martínez-Marchal, Ana, Aivio, Suvi, Palenzuela, Lluís, Wolfrum, Uwe, McKinnon, Peter J., Suja, José A., Roig, Ignasi, Costanzo, Vincenzo, Lüders, Jens, Stracker, Travis H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4499871/
https://ncbi.nlm.nih.gov/pubmed/26158450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms8676
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