Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly

Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instabilit...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cell Rep
Prif Awduron: Bianchi, Federico Tommaso, Tocco, Chiara, Pallavicini, Gianmarco, Liu, Yifan, Vernì, Fiammetta, Merigliano, Chiara, Bonaccorsi, Silvia, El-Assawy, Nadia, Priano, Lorenzo, Gai, Marta, Berto, Gaia Elena, Chiotto, Alessandra Maria Adelaide, Sgrò, Francesco, Caramello, Alessia, Tasca, Laura, Ala, Ugo, Neri, Francesco, Oliviero, Salvatore, Mauro, Alessandro, Geley, Stephan, Gatti, Maurizio, Di Cunto, Ferdinando
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Cell Press 2017
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318669/
https://ncbi.nlm.nih.gov/pubmed/28199840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.054
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