Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly

Mutations in citron (CIT), leading to loss or inactivation of the citron kinase protein (CITK), cause primary microcephaly in humans and rodents, associated with cytokinesis failure and apoptosis in neural progenitors. We show that CITK loss induces DNA damage accumulation and chromosomal instabilit...

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Publicat a:Cell Rep
Autors principals: Bianchi, Federico Tommaso, Tocco, Chiara, Pallavicini, Gianmarco, Liu, Yifan, Vernì, Fiammetta, Merigliano, Chiara, Bonaccorsi, Silvia, El-Assawy, Nadia, Priano, Lorenzo, Gai, Marta, Berto, Gaia Elena, Chiotto, Alessandra Maria Adelaide, Sgrò, Francesco, Caramello, Alessia, Tasca, Laura, Ala, Ugo, Neri, Francesco, Oliviero, Salvatore, Mauro, Alessandro, Geley, Stephan, Gatti, Maurizio, Di Cunto, Ferdinando
Format: Artigo
Idioma:Inglês
Publicat: Cell Press 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5318669/
https://ncbi.nlm.nih.gov/pubmed/28199840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.01.054
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