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Activation of the apoptotic pathway during prolonged prometaphase blocks daughter cell proliferation

When untransformed human cells spend >1.5 h in prometaphase under standard culture conditions, all daughters arrest in G1 despite normal division of their mothers. We investigate what happens during prolonged prometaphase that leads to daughter cell arrest in the absence of DNA damage. We find th...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Uetake, Yumi, Sluder, Greenfield
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249836/
https://ncbi.nlm.nih.gov/pubmed/30133342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-01-0026
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