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A Rnd3/p190RhoGAP pathway regulates RhoA activity in idiopathic pulmonary fibrosis fibroblasts

Idiopathic pulmonary fibrosis (IPF) is an incurable disease of the lung that is characterized by excessive deposition of extracellular matrix (ECM), resulting in disruption of normal lung function. The signals regulating fibrosis include both transforming growth factor beta (TGF-β) and tissue rigidi...

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Bibliografiske detaljer
Udgivet i:Mol Biol Cell
Main Authors: Monaghan-Benson, Elizabeth, Wittchen, Erika S., Doerschuk, Claire M., Burridge, Keith
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Cell Biology 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249798/
https://ncbi.nlm.nih.gov/pubmed/29995590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-11-0642
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