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A Rnd3/p190RhoGAP pathway regulates RhoA activity in idiopathic pulmonary fibrosis fibroblasts

Idiopathic pulmonary fibrosis (IPF) is an incurable disease of the lung that is characterized by excessive deposition of extracellular matrix (ECM), resulting in disruption of normal lung function. The signals regulating fibrosis include both transforming growth factor beta (TGF-β) and tissue rigidi...

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Bibliographic Details
Published in:Mol Biol Cell
Main Authors: Monaghan-Benson, Elizabeth, Wittchen, Erika S., Doerschuk, Claire M., Burridge, Keith
Format: Artigo
Language:Inglês
Published: The American Society for Cell Biology 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249798/
https://ncbi.nlm.nih.gov/pubmed/29995590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-11-0642
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