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A Rnd3/p190RhoGAP pathway regulates RhoA activity in idiopathic pulmonary fibrosis fibroblasts

Idiopathic pulmonary fibrosis (IPF) is an incurable disease of the lung that is characterized by excessive deposition of extracellular matrix (ECM), resulting in disruption of normal lung function. The signals regulating fibrosis include both transforming growth factor beta (TGF-β) and tissue rigidi...

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Detalhes bibliográficos
Publicado no:Mol Biol Cell
Main Authors: Monaghan-Benson, Elizabeth, Wittchen, Erika S., Doerschuk, Claire M., Burridge, Keith
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Cell Biology 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6249798/
https://ncbi.nlm.nih.gov/pubmed/29995590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-11-0642
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