Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit

Opioid-based therapies remain a mainstay for chronic pain management, but unwanted side effects limit therapeutic use. We compared efficacies of brain-permeant and -impermeant inhibitors of fatty acid amide hydrolase (FAAH) in suppressing neuropathic pain induced by the chemotherapeutic agent paclit...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Slivicki, Richard A., Saberi, Shahin A., Iyer, Vishakh, Vemuri, V. Kiran, Makriyannis, Alexandros, Hohmann, Andrea G.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2018
Assuntos:
Neuropharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6246979/
https://ncbi.nlm.nih.gov/pubmed/30275151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.118.252288
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