A carregar...
Approximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH)
A structure-based drug discovery method is described that incorporates target flexibility through the use of an ensemble of protein conformations. The approach was applied to fatty acid amide hydrolase (FAAH), a key deactivating enzyme in the endocannabinoid system. The resultant dynamic pharmacopho...
Na minha lista:
| Main Authors: | , |
|---|---|
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3246545/ https://ncbi.nlm.nih.gov/pubmed/22098169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci200371z |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|