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Approximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH)
A structure-based drug discovery method is described that incorporates target flexibility through the use of an ensemble of protein conformations. The approach was applied to fatty acid amide hydrolase (FAAH), a key deactivating enzyme in the endocannabinoid system. The resultant dynamic pharmacopho...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2011
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3246545/ https://ncbi.nlm.nih.gov/pubmed/22098169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci200371z |
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