Sulfonyl Fluoride Inhibitors of Fatty Acid Amide Hydrolase

Sulfonyl fluorides are known to inhibit esterases. Early work from our laboratory has identified hexadecyl sulfonylfluoride (AM374) as a potent in vitro and in vivo inhibitor of fatty acid amide hydrolase (FAAH). We now report on later generation sulfonyl fluoride analogs that exhibit potent and sel...

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Auteurs principaux: Alapafuja, Shakiru O., Nikas, Spyros P., Bharatan, Indu, Shukla, Vidyanand G., Nasr, Mahmoud L., Bowman, Anna L., Zvonok, Nikolai, Li, Jing, Shi, Xiaomeng, Engen, John R., Makriyannis, Alexandros
Format: Artigo
Langue:Inglês
Publié: 2012
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3678964/
https://ncbi.nlm.nih.gov/pubmed/23083016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm301205j
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