Загрузка...
Approximating protein flexibility through dynamic pharmacophore models: application to fatty acid amide hydrolase (FAAH)
A structure-based drug discovery method is described that incorporates target flexibility through the use of an ensemble of protein conformations. The approach was applied to fatty acid amide hydrolase (FAAH), a key deactivating enzyme in the endocannabinoid system. The resultant dynamic pharmacopho...
Сохранить в:
| Главные авторы: | , |
|---|---|
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3246545/ https://ncbi.nlm.nih.gov/pubmed/22098169 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci200371z |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|