A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase

Fatty-acid amide hydrolase (FAAH) is the major enzyme responsible for degradation of anandamide, an endocannabinoid. Pharmacological inhibition or genetic deletion of FAAH (FAAH KO) produces antinociception in preclinical pain models that is largely attributed to anandamide-induced activation of can...

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Udgivet i:Mol Pain
Main Authors: Carey, Lawrence M, Slivicki, Richard A, Leishman, Emma, Cornett, Ben, Mackie, Ken, Bradshaw, Heather, Hohmann, Andrea G
Format: Artigo
Sprog:Inglês
Udgivet: SAGE Publications 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956176/
https://ncbi.nlm.nih.gov/pubmed/27178246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806916649192
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