A pro-nociceptive phenotype unmasked in mice lacking fatty-acid amide hydrolase

Fatty-acid amide hydrolase (FAAH) is the major enzyme responsible for degradation of anandamide, an endocannabinoid. Pharmacological inhibition or genetic deletion of FAAH (FAAH KO) produces antinociception in preclinical pain models that is largely attributed to anandamide-induced activation of can...

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發表在:Mol Pain
Main Authors: Carey, Lawrence M, Slivicki, Richard A, Leishman, Emma, Cornett, Ben, Mackie, Ken, Bradshaw, Heather, Hohmann, Andrea G
格式: Artigo
語言:Inglês
出版: SAGE Publications 2016
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Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4956176/
https://ncbi.nlm.nih.gov/pubmed/27178246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1744806916649192
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