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Divergent TCR-Initiated Calcium Signals Govern Recruitment vs. Activation of Human Alloreactive Effector Memory T cells by Endothelial Cells

Early human allograft rejection can be initiated when circulating human host vs. graft antigen-specific CD8 and CD4 effector memory T cells (T(EM)) directly recognize MHC Class I and II, respectively, expressed on the luminal surface by endothelium lining graft blood vessels. TCR engagement triggers...

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Détails bibliographiques
Publié dans:J Immunol
Auteurs principaux: Manes, Thomas D., Wang, Vivian, Pober, Jordan S.
Format: Artigo
Langue:Inglês
Publié: 2018
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6246797/
https://ncbi.nlm.nih.gov/pubmed/30341183
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1800223
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