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Polarized granzyme release is required for antigen-driven transendothelial migration of human effector memory CD4 T cells

Human effector memory (EM) CD4 T cells may transmigrate across endothelial cell (EC) monolayers either in response to inflammatory chemokines or in response to TCR recognition of antigen presented on the surface of the EC. The kinetics, morphologic manifestations, and molecular requirements of chemo...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Manes, Thomas D., Pober, Jordan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4258477/
https://ncbi.nlm.nih.gov/pubmed/25367116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1401665
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