Kaposi's Sarcoma-associated Herpesvirus K3 and K5 Proteins Block Distinct Steps in Transendothelial Migration of Effector Memory CD4+ T cells by Targeting Different Endothelial Proteins

K3 and K5 are Kaposi's sarcoma-associated herpesvirus (KSHV)-encoded E3 ubiquitin ligases that differentially reduce surface expression of various proteins in infected cells. Here we describe their effects on human dermal microvascular endothelial cells (HDMEC), a natural target of KSHV infecti...

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Autores principales: Manes, Thomas D., Hoer, Simon, Muller, William A., Lehner, Paul J., Pober, Jordan S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2877909/
https://ncbi.nlm.nih.gov/pubmed/20357254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.0902938
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