Ryanodine receptor dispersion disrupts Ca(2+) release in failing cardiac myocytes

Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca(2+) release from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to nanoscale RyR reorganization. Using super-resolution imaging, we observed dispersion of RyR clusters in cardiomyocytes f...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kolstad, Terje R, van den Brink, Jonas, MacQuaide, Niall, Lunde, Per Kristian, Frisk, Michael, Aronsen, Jan Magnus, Norden, Einar S, Cataliotti, Alessandro, Sjaastad, Ivar, Sejersted, Ole M, Edwards, Andrew G, Lines, Glenn Terje, Louch, William E
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245731/
https://ncbi.nlm.nih.gov/pubmed/30375974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39427
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