Ryanodine receptor dispersion disrupts Ca(2+) release in failing cardiac myocytes

Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca(2+) release from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to nanoscale RyR reorganization. Using super-resolution imaging, we observed dispersion of RyR clusters in cardiomyocytes f...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Kolstad, Terje R, van den Brink, Jonas, MacQuaide, Niall, Lunde, Per Kristian, Frisk, Michael, Aronsen, Jan Magnus, Norden, Einar S, Cataliotti, Alessandro, Sjaastad, Ivar, Sejersted, Ole M, Edwards, Andrew G, Lines, Glenn Terje, Louch, William E
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2018
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245731/
https://ncbi.nlm.nih.gov/pubmed/30375974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39427
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