Ryanodine receptor dispersion disrupts Ca(2+) release in failing cardiac myocytes

Reduced cardiac contractility during heart failure (HF) is linked to impaired Ca(2+) release from Ryanodine Receptors (RyRs). We investigated whether this deficit can be traced to nanoscale RyR reorganization. Using super-resolution imaging, we observed dispersion of RyR clusters in cardiomyocytes f...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:eLife
Egile Nagusiak: Kolstad, Terje R, van den Brink, Jonas, MacQuaide, Niall, Lunde, Per Kristian, Frisk, Michael, Aronsen, Jan Magnus, Norden, Einar S, Cataliotti, Alessandro, Sjaastad, Ivar, Sejersted, Ole M, Edwards, Andrew G, Lines, Glenn Terje, Louch, William E
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: eLife Sciences Publications, Ltd 2018
Gaiak:
Cell Biology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245731/
https://ncbi.nlm.nih.gov/pubmed/30375974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.39427
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