Synchrony of Cardiomyocyte Ca(2+) Release is Controlled by t-tubule Organization, SR Ca(2+) Content, and Ryanodine Receptor Ca(2+) Sensitivity

Recent work has demonstrated that cardiomyocyte Ca(2+)release is desynchronized in several pathological conditions. Loss of Ca(2+) release synchrony has been attributed to t-tubule disruption, but it is unknown if other factors also contribute. We investigated this issue in normal and failing myocyt...

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Hlavní autoři: Øyehaug, Leiv, Loose, Kristian Ø., Jølle, Guro F., Røe, Åsmund T., Sjaastad, Ivar, Christensen, Geir, Sejersted, Ole M., Louch, William E.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2013
Témata:
Channels and Transporters
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3627865/
https://ncbi.nlm.nih.gov/pubmed/23601316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.03.022
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