Extreme sarcoplasmic reticulum volume loss and compensatory T-tubule remodeling after Serca2 knockout

Cardiomyocyte contraction and relaxation are controlled by Ca(2+) handling, which can be regulated to meet demand. Indeed, major reduction in sarcoplasmic reticulum (SR) function in mice with Serca2 knockout (KO) is compensated by enhanced plasmalemmal Ca(2+) fluxes. Here we investigate whether alte...

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Detalhes bibliográficos
Main Authors: Swift, Fredrik, Franzini-Armstrong, Clara, Øyehaug, Leiv, Enger, Ulla Helene, Andersson, Kristin Brevik, Christensen, Geir, Sejersted, Ole M., Louch, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3309775/
https://ncbi.nlm.nih.gov/pubmed/22355118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1120172109
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