Beta-Adrenergic Stimulation Maintains Cardiac Function in Serca2 Knockout Mice

Previous studies on Serca2 knockout (KO) mice showed that cardiac function is sustained in vivo for several weeks after knockout, whereas SERCA protein levels decrease and calcium dynamics are significantly impaired. In this study, we reconcile observed cellular and organ level contractile function...

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Main Authors: Land, Sander, Louch, William E., Niederer, Steven A., Aronsen, Jan Magnus, Christensen, Geir, Sjaastad, Ivar, Sejersted, Ole M., Smith, Nicolas P.
格式: Artigo
語言:Inglês
出版: The Biophysical Society 2013
主題:
Systems Biophysics
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602781/
https://ncbi.nlm.nih.gov/pubmed/23528094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2013.01.042
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