Effect of Dehydroaltenusin-C12 Derivative, a Selective DNA Polymerase α Inhibitor, on DNA Replication in Cultured Cells

Dehydroaltenusin is a selective inhibitor of mammalian DNA polymerase α (pol α) from a fungus (Alternaria tennuis). We have designed, synthesized, and characterized a derivative of dehydroaltenusin conjugated with a C12-alkyl side chain (dehydroaltenusin-C12 [C12]). C12 was the strongest pol α inhib...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Kuriyama, Isoko, Mizuno, Takeshi, Fukudome, Keishi, Kuramochi, Kouji, Tsubaki, Kazunori, Usui, Takeo, Imamoto, Naoko, Sakaguchi, Kengo, Sugawara, Fumio, Yoshida, Hiromi, Mizushina, Yoshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245447/
https://ncbi.nlm.nih.gov/pubmed/19043348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules13122948
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