Effects of Intermediates between Vitamins K2 and K3 on Mammalian DNA Polymerase Inhibition and Anti-Inflammatory Activity

Previously, we reported that vitamin K3 (VK3), but not VK1 or VK2 (=MK-4), inhibits the activity of human DNA polymerase γ (pol γ). In this study, we chemically synthesized three intermediate compounds between VK2 and VK3, namely MK-3, MK-2 and MK-1, and investigated the inhibitory effects of all fi...

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Autors principals: Takeshi Azuma, Hiromi Yoshida, Masaru Yoshida, Isoko Kuriyama, Kazunori Tsubaki, Yasuyuki Kondo, Kazuyuki Nishio, Kouji Kuramochi, Shin Nishiumi, Masayuki Nishida, Yasuhiro Irino, Yoshiyuki Mizushina, Jun Maeda
Format: Artigo
Idioma:Inglês
Publicat: MDPI AG 2011-02-01
Col·lecció:International Journal of Molecular Sciences
Matèries:
vitamin K
MK-2
DNA polymerase λ
enzyme inhibitor
anti-inflammation
Accés en línia:http://www.mdpi.com/1422-0067/12/2/1115/
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