Anti-Tumor Effects of Novel 5-O-Acyl Plumbagins Based on the Inhibition of Mammalian DNA Replicative Polymerase Activity

We previously found that vitamin K(3) (menadione, 2-methyl-1,4-naphthoquinone) inhibits the activity of human mitochondrial DNA polymerase γ (pol γ). In this study, we focused on plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone), and chemically synthesized novel plumbagins conjugated with C2:0 to C2...

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Bibliographic Details
Main Authors: Kawamura, Moe, Kuriyama, Isoko, Maruo, Sayako, Kuramochi, Kouji, Tsubaki, Kazunori, Yoshida, Hiromi, Mizushina, Yoshiyuki
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3919815/
https://ncbi.nlm.nih.gov/pubmed/24520419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0088736
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