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Structure and Catalytic Properties of Carboxylesterase Isozymes Involved in Metabolic Activation of Prodrugs

Mammalian carboxylesterases (CESs) comprise a multigene family whose gene products play important roles in biotransformation of ester- or amide-type prodrugs. They are members of an α,β-hydrolase-fold family and are found in various mammals. It has been suggested that CESs can be classified into fiv...

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Bibliographic Details
Published in:Molecules
Main Author: Hosokawa, Masakiyo
Format: Artigo
Language:Inglês
Published: MDPI 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6245361/
https://ncbi.nlm.nih.gov/pubmed/18305428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules13020412
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