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Interspecies Differences in the Metabolism of a Multi-Ester Prodrug by Carboxylesterases
The penta-ethyl ester prodrug of the chelating agent diethylene triamine pentaacetic acid (DTPA) referred to as C2E5, is being developed as an orally bioavailable radionuclide decorporation agent. The predicted human efficacy obtained in these experimental animals is confounded by interspecies varia...
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| Published in: | J Pharm Sci |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4781669/ https://ncbi.nlm.nih.gov/pubmed/26344572 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24632 |
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