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Interspecies Differences in the Metabolism of a Multi-Ester Prodrug by Carboxylesterases

The penta-ethyl ester prodrug of the chelating agent diethylene triamine pentaacetic acid (DTPA) referred to as C2E5, is being developed as an orally bioavailable radionuclide decorporation agent. The predicted human efficacy obtained in these experimental animals is confounded by interspecies varia...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Pharm Sci
Egile Nagusiak: Fu, Jing, Pacyniak, Erik, Leed, Marina G. D., Sadgrove, Matthew P., Marson, Lesley, Jay, Michael
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4781669/
https://ncbi.nlm.nih.gov/pubmed/26344572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24632
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