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Single-molecule force spectroscopy reveals folding steps associated with hormone binding and activation of the glucocorticoid receptor
The glucocorticoid receptor (GR) is a prominent nuclear receptor linked to a variety of diseases and an important drug target. Binding of hormone to its ligand binding domain (GR-LBD) is the key activation step to induce signaling. This process is tightly regulated by the molecular chaperones Hsp70...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6243279/ https://ncbi.nlm.nih.gov/pubmed/30366952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1807618115 |
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