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Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy
In this study we expand the accessible dynamic range of single-molecule force spectroscopy by optical tweezers to the microsecond range by fast sampling. We are able to investigate a single molecule for up to 15 min and with 300-kHz bandwidth as the protein undergoes tens of millions of folding/unfo...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3831443/ https://ncbi.nlm.nih.gov/pubmed/24145407 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1311495110 |
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