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A folding nucleus and minimal ATP binding domain of Hsp70 identified by single-molecule force spectroscopy

The folding pathways of large proteins are complex, with many of them requiring the aid of chaperones and others folding spontaneously. Along the folding pathways, partially folded intermediates are frequently populated; their role in the driving of the folding process is unclear. The structures of...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Bauer, Daniela, Meinhold, Sarah, Jakob, Roman P., Stigler, Johannes, Merkel, Ulrich, Maier, Timm, Rief, Matthias, Žoldák, Gabriel
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2018
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5939067/
https://ncbi.nlm.nih.gov/pubmed/29669923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1716899115
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