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Nanomechanics of the substrate binding domain of Hsp70 determine its allosteric ATP-induced conformational change
Owing to the cooperativity of protein structures, it is often almost impossible to identify independent subunits, flexible regions, or hinges simply by visual inspection of static snapshots. Here, we use single-molecule force experiments and simulations to apply tension across the substrate binding...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5468673/ https://ncbi.nlm.nih.gov/pubmed/28533394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1619843114 |
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