Nucleotides regulate the mechanical hierarchy between subdomains of the nucleotide binding domain of the Hsp70 chaperone DnaK

The regulation of protein function through ligand-induced conformational changes is crucial for many signal transduction processes. The binding of a ligand alters the delicate energy balance within the protein structure, eventually leading to such conformational changes. In this study, we elucidate...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Bauer, Daniela, Merz, Dale R., Pelz, Benjamin, Theisen, Kelly E., Yacyshyn, Gail, Mokranjac, Dejana, Dima, Ruxandra I., Rief, Matthias, Žoldák, Gabriel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4547238/
https://ncbi.nlm.nih.gov/pubmed/26240360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1504625112
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