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Folding and assembly of the large molecular machine Hsp90 studied in single-molecule experiments

Folding of small proteins often occurs in a two-state manner and is well understood both experimentally and theoretically. However, many proteins are much larger and often populate misfolded states, complicating their folding process significantly. Here we study the complete folding and assembly pro...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Jahn, Markus, Buchner, Johannes, Hugel, Thorsten, Rief, Matthias
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4747692/
https://ncbi.nlm.nih.gov/pubmed/26787848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1518827113
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