Switchable control over in vivo CAR T expansion, B cell depletion, and induction of memory

Chimeric antigen receptor (CAR) T cells with a long-lived memory phenotype are correlated with durable, complete remissions in patients with leukemia. However, not all CAR T cell products form robust memory populations, and those that do can induce chronic B cell aplasia in patients. To address thes...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Viaud, Sophie, Ma, Jennifer S. Y., Hardy, Ian R., Hampton, Eric N., Benish, Brent, Sherwood, Lance, Nunez, Vanessa, Ackerman, Christopher J., Khialeeva, Elvira, Weglarz, Meredith, Lee, Sung Chang, Woods, Ashley K., Young, Travis S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6243241/
https://ncbi.nlm.nih.gov/pubmed/30373813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810060115
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