Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related to the inability to control CAR-T cells once infused into the patient remain a significant challenge. Here we report the engineering of recomb...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Rodgers, David T., Mazagova, Magdalena, Hampton, Eric N., Cao, Yu, Ramadoss, Nitya S., Hardy, Ian R., Schulman, Andrew, Du, Juanjuan, Wang, Feng, Singer, Oded, Ma, Jennifer, Nunez, Vanessa, Shen, Jiayin, Woods, Ashley K., Wright, Timothy M., Schultz, Peter G., Kim, Chan Hyuk, Young, Travis S.
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2016
主題:
PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743815/
https://ncbi.nlm.nih.gov/pubmed/26759369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524155113
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