Switch-mediated activation and retargeting of CAR-T cells for B-cell malignancies

Chimeric antigen receptor T (CAR-T) cell therapy has produced impressive results in clinical trials for B-cell malignancies. However, safety concerns related to the inability to control CAR-T cells once infused into the patient remain a significant challenge. Here we report the engineering of recomb...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Rodgers, David T., Mazagova, Magdalena, Hampton, Eric N., Cao, Yu, Ramadoss, Nitya S., Hardy, Ian R., Schulman, Andrew, Du, Juanjuan, Wang, Feng, Singer, Oded, Ma, Jennifer, Nunez, Vanessa, Shen, Jiayin, Woods, Ashley K., Wright, Timothy M., Schultz, Peter G., Kim, Chan Hyuk, Young, Travis S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4743815/
https://ncbi.nlm.nih.gov/pubmed/26759369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524155113
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