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Engineering switchable and programmable universal CARs for CAR T therapy
A traditional chimeric antigen receptor (CAR) has a fixed design, and one type of CAR T cells can only target one antigen epitope. This rigid design limits clinical application and leads to exceptionally high manufacturing cost. New CARs are being engineered with a modular approach so that the antig...
Guardat en:
| Publicat a: | J Hematol Oncol |
|---|---|
| Autors principals: | , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
BioMed Central
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6610960/ https://ncbi.nlm.nih.gov/pubmed/31272471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0763-0 |
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