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Chemically programmable and switchable CAR-T therapy

Although the cell surfaceome is predominantly targeted and drugged with antibodies, its pocketome fraction is only accessible to small molecules and constitutes a rich subset of binding sites with immense potential diagnostic and therapeutic utility. Compared to antibodies, however, small molecules...

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Dades bibliogràfiques
Publicat a:Angew Chem Int Ed Engl
Autors principals: Qi, Junpeng, Tsuji, Kohei, Hymel, David, Burke, Terrence R., Hudecek, Michael, Rader, Christoph, Peng, Haiyong
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7429910/
https://ncbi.nlm.nih.gov/pubmed/32329959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202005432
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