Enantioselective Synthesis of Biaryl Atropisomers via the Addition of Thiophenols into Aryl-Naphthoquinones

We report a cinchona alkaloid catalyzed addition of thiophenol into rapidly interconverting aryl-naphthoquinones, resulting in stable biaryl atropisomers upon reductive methylation. An array of thiophenols and naphthoquinone substrates were evaluated, and we observed selectivities up to 98.5:1.5 e.r...

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Publicado en:ACS Catal
Main Authors: Maddox, Sean M., Dawson, Gregory A., Rochester, Nicholas C., Ayonon, Arianna B., Moore, Curtis E., Rheingold, Arnold L., Gustafson, Jeffrey L.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238969/
https://ncbi.nlm.nih.gov/pubmed/30455999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscatal.8b00906
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