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Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination

Despite the widespread use of axially chiral, or atropisomeric, biaryl ligands in modern synthesis, and the occurrence of numerous natural products exhibiting axial chirality, general catalytic methods for the direct asymmetric preparation of this compound class have proven elusive. Here we present...

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Main Authors: Gustafson, Jeffrey L., Lim, Daniel, Miller, Scott J.
格式: Artigo
語言:Inglês
出版: 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066098/
https://ncbi.nlm.nih.gov/pubmed/20522769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1188403
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