Enzymatic Desymmetrising Redox Reactions for the Asymmetric Synthesis of Biaryl Atropisomers

Atropisomeric biaryls carrying ortho-hydroxymethyl and formyl groups were made enantioselectively by desymmetrisation of dialdehyde or diol substrates. The oxidation of the symmetrical diol substrates was achieved using a variant of galactose oxidase (GOase), and the reduction of the dialdehydes usi...

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Détails bibliographiques
Publié dans:Chemistry
Auteurs principaux: Staniland, Samantha, Yuan, Bo, Giménez-Agulló, Nelson, Marcelli, Tommaso, Willies, Simon C, Grainger, Damian M, Turner, Nicholas J, Clayden, Jonathan
Format: Artigo
Langue:Inglês
Publié: WILEY-VCH Verlag 2014
Sujets:
Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4497317/
https://ncbi.nlm.nih.gov/pubmed/25156181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/chem.201404509
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