Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

New antitubercular agents are needed to combat the spread of multidrug- and extensively drug-resistant strains of Mycobacterium tuberculosis. The frontline antitubercular drug isoniazid (INH) targets the mycobacterial enoyl-ACP reductase, InhA. Resistance to INH is predominantly through mutations af...

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Foilsithe in:Life Sci Alliance
Main Authors: Xia, Yi, Zhou, Yasheen, Carter, David S, McNeil, Matthew B, Choi, Wai, Halladay, Jason, Berry, Pamela W, Mao, Weimin, Hernandez, Vincent, O'Malley, Theresa, Korkegian, Aaron, Sunde, Bjorn, Flint, Lindsay, Woolhiser, Lisa K, Scherman, Michael S, Gruppo, Veronica, Hastings, Courtney, Robertson, Gregory T, Ioerger, Thomas R, Sacchettini, Jim, Tonge, Peter J, Lenaerts, Anne J, Parish, Tanya, Alley, MRK
Formáid: Artigo
Teanga:Inglês
Foilsithe: Life Science Alliance LLC 2018
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238539/
https://ncbi.nlm.nih.gov/pubmed/30456352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800025
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