Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

New antitubercular agents are needed to combat the spread of multidrug- and extensively drug-resistant strains of Mycobacterium tuberculosis. The frontline antitubercular drug isoniazid (INH) targets the mycobacterial enoyl-ACP reductase, InhA. Resistance to INH is predominantly through mutations af...

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Bibliographic Details
Published in:Life Sci Alliance
Main Authors: Xia, Yi, Zhou, Yasheen, Carter, David S, McNeil, Matthew B, Choi, Wai, Halladay, Jason, Berry, Pamela W, Mao, Weimin, Hernandez, Vincent, O'Malley, Theresa, Korkegian, Aaron, Sunde, Bjorn, Flint, Lindsay, Woolhiser, Lisa K, Scherman, Michael S, Gruppo, Veronica, Hastings, Courtney, Robertson, Gregory T, Ioerger, Thomas R, Sacchettini, Jim, Tonge, Peter J, Lenaerts, Anne J, Parish, Tanya, Alley, MRK
Format: Artigo
Language:Inglês
Published: Life Science Alliance LLC 2018
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6238539/
https://ncbi.nlm.nih.gov/pubmed/30456352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.26508/lsa.201800025
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