Coordinated protein and DNA conformational changes govern mismatch repair initiation by MutS

MutS homologs identify base-pairing errors made in DNA during replication and initiate their repair. In the presence of adenosine triphosphate, MutS induces DNA bending upon mismatch recognition and subsequently undergoes conformational transitions that promote its interaction with MutL to signal re...

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Vydáno v:Nucleic Acids Res
Hlavní autoři: LeBlanc, Sharonda J, Gauer, Jacob W, Hao, Pengyu, Case, Brandon C, Hingorani, Manju M, Weninger, Keith R, Erie, Dorothy A
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2018
Témata:
Genome Integrity, Repair and Replication
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6237781/
https://ncbi.nlm.nih.gov/pubmed/30272207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky865
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