Recurrent mismatch binding by MutS mobile clamps on DNA localizes repair complexes nearby

DNA mismatch repair (MMR), the guardian of the genome, commences when MutS identifies a mismatch and recruits MutL to nick the error-containing strand, allowing excision and DNA resynthesis. Dominant MMR models posit that after mismatch recognition, ATP converts MutS to a hydrolysis-independent, dif...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Hao, Pengyu, LeBlanc, Sharonda J., Case, Brandon C., Elston, Timothy C., Hingorani, Manju M., Erie, Dorothy A., Weninger, Keith R.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2020
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7395554/
https://ncbi.nlm.nih.gov/pubmed/32669440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1918517117
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