Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signalling

MutS protein recognizes mispaired bases in DNA and targets them for mismatch repair. Little is known about the transient conformations of MutS as it signals initiation of repair. We have used single-molecule fluorescence resonance energy transfer (FRET) measurements to report the conformational dyna...

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Autori principali: Qiu, Ruoyi, DeRocco, Vanessa C, Harris, Credle, Sharma, Anushi, Hingorani, Manju M, Erie, Dorothy A, Weninger, Keith R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365432/
https://ncbi.nlm.nih.gov/pubmed/22505031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.95
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