Large conformational changes in MutS during DNA scanning, mismatch recognition and repair signalling

MutS protein recognizes mispaired bases in DNA and targets them for mismatch repair. Little is known about the transient conformations of MutS as it signals initiation of repair. We have used single-molecule fluorescence resonance energy transfer (FRET) measurements to report the conformational dyna...

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Bibliografiske detaljer
Main Authors: Qiu, Ruoyi, DeRocco, Vanessa C, Harris, Credle, Sharma, Anushi, Hingorani, Manju M, Erie, Dorothy A, Weninger, Keith R
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3365432/
https://ncbi.nlm.nih.gov/pubmed/22505031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.95
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